infections after laparoscopic and open cholecystectomy: ceftriaxone versus placebo; a double blind randomized clinical trial

نویسندگان

mohammad mozafar cancer research center, shahid beheshti university of medical sciences, tehran, ir iran; department of general surgery, shohada-e-tajrish hospital, tajrish square, tehran, iran.

mohammad reza sobhiyeh cancer research center, shahid beheshti university of medical sciences, tehran, ir iran

leili hafezi moghadam cancer research center, shahid beheshti university of medical sciences, tehran, ir iran

چکیده

conclusion it can be concluded that prophylactic antibiotics do not have any preventive effect on wound infection in a double blind setting. according to our findings, routine antibiotic prophylaxis as recommended for biliary surgery (open or laparoscopic cholecystectomy) is now questionable. results the study population included 61 males and 69 females with the mean age of 49.3±9.6 and 51.8±9.9 years in treatment and placebo group, respectively. of 130 bile culture results, 83 were negative. escherichia coli, klebsiella and staphylococcus aureus were the most common cultured bacteria. there was no statistically significant difference in culture results between the patients received ab and placebo (ns). the surgical technique (open versus laparoscopic) did not influence the culture results. patients and methods in this double blind randomized clinical trial, we studied 130 patients with symptomatic cholelithiasis or polyps of gallbladder admitted in shohada-e-tajrish hospital, tehran, iran for cholecystectomy between 2006 and 2008. patients were randomly assigned in two subgroups: the first group received 1gr ceftriaxone during induction of anesthesia and the second group received 10ml of isotonic sodium chlorides solution as placebo. all patients were followed for 4 weeks after surgery. background gallstone disease is one of the most common gastrointestinal diseases requiring surgery with probable postoperative infection. the role of prophylactic antibiotics (ab) in prevention of infection is controversial. this study aimed to compare the manifestations, complications and outcomes of two groups of patients, those receiving prophylactic ab versus placebo, in order to determine whether antibiotic therapy is required.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparing the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy: A double-blind clinical trial

Introduction: Nausea and vomiting are conditions that could occur after anesthesia and lead to reduced activity and surgery dissatisfaction. Therefore, according to its importance, this study was accomplished in order to compere the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy. Materials and Methods: This study was a double-blind...

متن کامل

Comparison between Golnar product and placebo in heavy menstrual bleeding: A double-blind randomized clinical trial

Objective: Golnar product is a poly herbal formulation advised by Persian medicine to control heavy menstrual bleeding (HMB). This study was conducted to compare the efficacy of this product with placebo in patients with HMB. Materials and Methods: In this double-blind randomized clinical trial, 100 women with HMB were randomly assigned into two groups. T...

متن کامل

The Effect of Mint Product on Pain Relief after Elective Cholecystectomy- A Double Blind Clinical Trial

Background: Bloating (emphysema) is one of the causes of postoperative cholecystectomy. Studies show that despite various analgesics, 77% of patients hospitalized at surgery and internal wards suffer from pain, for which different drugs can be used to relief the pain. Mint is one of the herbal remedies used for the treatment of bloating (emphysema). Due to the anti-inflammatory and analgesic ef...

متن کامل

Effect of oral ginger on prevention of nausea and vomiting after laparoscopic cholecystectomy: a double-blind, randomized, placebo-controlled trial

Background Postoperative nausea and vomiting (PONV) are among the most frequent complications following laparoscopic cholecystectomy. Recently, some studies have shown ginger, as an herbal medicine, to be effective and safe in PONV prevention; however, there is no evidence of its efficacy in the Iranian population. Objective The aim of this study was to determine the effect of oral ginger on ...

متن کامل

single-incision laparoscopic cholecystectomy versus mini-laparoscopic cholecystectomy: a randomized clinical trial study

background: surgical technique using small-diameter  instruments and single-incision laparoscopy are two new options for less invasive laparoscopic cholecystectomy (lc). in this study, we have compared mini-lc (mlc) with single-incision lc (silc). materials and methods: this study is a randomized clinical trial conducted on the patients diagnosed with  symptomatic cholelithiasis who underwent l...

متن کامل

Laparoscopic versus open appendectomy: a prospective randomized double-blind study.

SUMMARY BACKGROUND DATA The value of laparoscopy in appendicitis is not established. Studies suffer from multiple limitations. Our aim is to compare the safety and benefits of laparoscopic versus open appendectomy in a prospective randomized double blind study. METHODS Two hundred forty-seven patients were analyzed following either laparoscopic or open appendectomy. A standardized wound dress...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
archives of clinical infectious diseases

جلد ۵، شماره ۱، صفحات ۳-۸

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023